Michael D. Lesh

Founder and CEO


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Michael D. Lesh

Michael D. Lesh, SM MD FACC, is the founder and CEO of Syntegra and an Adjunct Professor of
Medicine at the University of California, San Francisco. Until recently, he also served as
Executive Director of Health Technology Innovation in the Office of Vice Chancellor there. Dr.
Lesh combines a background in biomedical engineering and computer science from MIT with a
career as a physician-scientist in cardiac electrophysiology. He received training at UCSF and
University of Pennsylvania.

Dr. Lesh is an accomplished inventor and entrepreneur, having founded and served as CEO of
several successful medtech companies, including Atrionix, Mitralife, Appriva Medical, Evera
Medical and Middle Peak Medical, many of which were later acquired by leading life sciences
companies. He also served as a director at HeartScape, Stentys, Abate, Cordance and

Dr. Lesh has authored over 200 scientific papers, book chapters and books, and he is an
inventor on over 250 patents, including the foundational method of atrial fibrillation ablation
and left atrial appendage occlusion to prevent stroke.

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